ea0025p167 | Diabetes, metabolism and cardiovascular | SFEBES2011
Jennings Rachel
, Berry Andrew
, Rodriguez Santiago
, Pasquali Lorenzo
, Moran Ignasi
, Roberts Neil
, Hanley Karen Piper
, Ferrer Jorge
, Hanley Neil
Understanding how fate choices are made by multipotent progenitors during pancreas development is valuable information in the quest for regenerative medicine and cell therapy to treat diabetes mellitus. Pancreatic differentiation is well defined and understood in rodents however, human data are comparably scarce. Specifically, when human pancreatic progenitors are multipotent is unknown as are the epigenetic changes that these cells undergo during their differentiation to beta...